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dynamic simulations simcyp v21  (Simcyp)

 
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    Simcyp dynamic simulations simcyp v21
    Dynamic Simulations Simcyp V21, supplied by Simcyp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/simcyp+v21+simulator/simcyp+v19/pmc11762507-60-25-26
    Average 90 stars, based on 1 article reviews
    dynamic simulations simcyp v21 - by Bioz Stars, 2026-10
    90/100 stars

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    other:

    Article Title: Impact of obesity and roux‐en‐Y gastric bypass on the pharmacokinetics of ( R )‐ and ( S )‐omeprazole and intragastric pH
    Article Snippet: PIPPA et al. | DOI: 10.1002/psp4.13189 5 TABLE S4 System parameters morbidly obese and post-gastric bypass patients implemented on Simcyp V21 simulator.

    Article Title: Metabolism Characterization and Chemical and Plasma Stability of Casearin B and Caseargrewiin F.
    Article Snippet: The predicted Peff, man values in the jejunum based on compound type, pKa, molecular weight, and log P was 15.8 × 10−4 and 16.7 × 10−4 cm/s (SimCYP V21 simulator).



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    Key PBPK modelling steps and components of each clinical study used in model development, refinement, verification and application. BCRP, breast cancer resistance protein; DDI, drug–drug interaction; fu inc , fraction of unbound dersimelagon in in vitro system; K m , Michaelis constant; MAD, multiple ascending dose; OATP, organic anion transporting polypeptide; PBPK, physiologically based pharmacokinetic; PK, pharmacokinetic; QD, once daily; V max , maximum velocity of reaction; V ss , volume of distribution at steady state.

    Journal: British Journal of Clinical Pharmacology

    Article Title: Physiologically based pharmacokinetic modelling to predict potential drug–drug interactions of dersimelagon (MT‐7117)

    doi: 10.1111/bcp.16271

    Figure Lengend Snippet: Key PBPK modelling steps and components of each clinical study used in model development, refinement, verification and application. BCRP, breast cancer resistance protein; DDI, drug–drug interaction; fu inc , fraction of unbound dersimelagon in in vitro system; K m , Michaelis constant; MAD, multiple ascending dose; OATP, organic anion transporting polypeptide; PBPK, physiologically based pharmacokinetic; PK, pharmacokinetic; QD, once daily; V max , maximum velocity of reaction; V ss , volume of distribution at steady state.

    Article Snippet: All simulations were conducted using the Simcyp PBPK Simulator v21 (Certara), which integrates demographic, physiological, genomic and in vitro biochemical data to allow prediction of PK in virtual healthy populations.

    Techniques: In Vitro

    Input parameters of the physiologically based pharmacokinetic model for dersimelagon.

    Journal: British Journal of Clinical Pharmacology

    Article Title: Physiologically based pharmacokinetic modelling to predict potential drug–drug interactions of dersimelagon (MT‐7117)

    doi: 10.1111/bcp.16271

    Figure Lengend Snippet: Input parameters of the physiologically based pharmacokinetic model for dersimelagon.

    Article Snippet: All simulations were conducted using the Simcyp PBPK Simulator v21 (Certara), which integrates demographic, physiological, genomic and in vitro biochemical data to allow prediction of PK in virtual healthy populations.

    Techniques: Binding Assay, Software, Permeability, In Vitro, Inhibition